Population pharmacokinetics of amikacin administered once-daily in patients with different renal function.
Conclusion: There is a wide variability in amikacin pharmacokinetic parameters in Mexican patients. This leads to inadequate dosing regimens specially in patients with augmented renal clearance (CLCr > 130 ml/min). Optimization based on final population pharmacokinetic model in Mexican patients may be useful since reliability and clinical applicability have been demonstrated in the current study.
PMID: 32041715 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Aréchiga-Alvarado NA, Medellín-Garibay SE, Milán-Segovia RDC, Ortiz-Álvarez A, Magaña-Aquino M, Romano-Moreno S Tags: Antimicrob Agents Chemother Source Type: research