Synergistic interactions of indole-2-carboxamides and β-lactam antibiotics against Mycobacterium abscessus.

Synergistic interactions of indole-2-carboxamides and β-lactam antibiotics against Mycobacterium abscessus.
Antimicrob Agents Chemother. 2020 Feb 10;:
Authors: Raynaud C, Daher W, Roquet-Banères F, Johansen MD, Stec J, Onajole OK, Ordway D, Kozikowski AP, Kremer L
Abstract
New drugs or therapeutic combinations are urgently needed against Mycobacterium abscessus Previously, we demonstrated the potent activity of indole-2-carboxamides 6 and 12 against M. abscessus. We show here that these compounds act synergistically with imipenem and cefoxitin in vitro and increase the bactericidal activity of the β-lactams against M. abscessus In addition, compound 12 also displays synergism with imipenem and cefoxitin within infected macrophages. The clinical potential of these new drug combinations requires further evaluation.
PMID: 32041716 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - February 9, 2020 Category: Microbiology Authors: Raynaud C, Daher W, Roquet-Banères F, Johansen MD, Stec J, Onajole OK, Ordway D, Kozikowski AP, Kremer L Tags: Antimicrob Agents Chemother Source Type: research