Perspectives of the potential implications of polyphenols in influencing the interrelationship between oxi-inflammatory stress, cellular senescence and immunosenescence during aging

Publication date: Available online 11 February 2020Source: Trends in Food Science &TechnologyAuthor(s): Rohit Sharma, Yogendra PadwadAbstractBackgroundThe multifactorial process of aging predisposes elderly to recurring infections and inflammatory disorders which ultimately affect quality of life and longevity. Dietary polyphenols are presently the forerunners for developing nutrition-based pro-longevity interventions due to their documented diverse health beneficial effects.Scope and approachStudies reviewing the accumulating anti-aging effects of polyphenols vis-à-vis our expanding understanding of the aging process are lacking. Therefore, the present review discusses the emerging interrelationship of oxi-inflammatory stress, cellular senescence and immunosenescence as the causal nexus of aging and explores the preventive and therapeutic role of polyphenols in mitigating these disorders. Polyphenols based pro-longevity approaches, targets and mechanisms have been reviewed.Key findings and conclusionsMolecular aetiology of aging is governed by the accumulation of senescent cells (SC), chronic oxi-inflammatory stress and immunosenescence. Polyphenols have shown multifaceted effects in attenuating the development and accumulation of SC, cellular oxidative stress as well as immune dysfunctions in several in vitro and in vivo studies. Evidence suggesting polyphenols mediated increase in lifespan through modulation of longevity pathways such as mTOR and calorie restric...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research

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