Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene [Microbiology]
A fundamental feature of life is that ribosomes read the genetic code in messenger RNA (mRNA) as triplets of nucleotides in a single reading frame. Mutations that shift the reading frame generally cause gene inactivation and in essential genes cause loss of viability. Here we report and characterize a +1-nt...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Douglas L. Huseby, Gerrit Brandis, Lisa Praski Alzrigat, Diarmaid Hughes Tags: Biological Sciences Source Type: research