Optimization of a Plasmodium falciparum circumsporozoite protein repeat vaccine using the tobacco mosaic virus platform [Immunology and Inflammation]

Plasmodium falciparum vaccine RTS,S/AS01 is based on the major NPNA repeat and the C-terminal region of the circumsporozoite protein (CSP). RTS,S-induced NPNA-specific antibody titer and avidity have been associated with high-level protection in naïve subjects, but efficacy and longevity in target populations is relatively low. In an effort to improve...

Source: Proceedings of the National Academy of Sciences - February 10, 2020 Category: Science Authors: Mark D. Langowski, Farhat A. Khan, Alexis A. Bitzer, Christopher J. Genito, Andrew J. Schrader, Monica L. Martin, Kimberly Soto, Xiaoyan Zou, Sri Hadiwidjojo, Zoltan Beck, Gary R. Matyas, Merricka C. Livingstone, Adrian H. Batchelor, Sheetij Dutta Tags: Biological Sciences Source Type: research