Dysregulation of TLR9 in neonates leads to fatal inflammatory disease driven by IFN-{gamma} [Immunology and Inflammation]

Recognition of self-nucleic acids by innate immune receptors can lead to the development of autoimmune and/or autoinflammatory diseases. Elucidating mechanisms associated with dysregulated activation of specific receptors may identify new disease correlates and enable more effective therapies. Here we describe an aggressive in vivo model of Toll-like receptor (TLR) 9...

Source: Proceedings of the National Academy of Sciences - February 10, 2020 Category: Science Authors: Alison G. Stanbery, Zachary R. Newman, Gregory M. Barton Tags: Biological Sciences Source Type: research