Sex-Specific Computational Models for Blood Pressure Regulation in the Rat.

Sex-Specific Computational Models for Blood Pressure Regulation in the Rat. Am J Physiol Renal Physiol. 2020 Feb 10;: Authors: Ahmed S, Layton AT Abstract In the past decades, substantial effect has been devoted to the development of computational models of the cardiovascular system. Some of these models simulate blood pressure regulation in humans and include components of the circulatory, renal, and neurohormonal systems. While such human models are intended to have clinical value in that they can be used to assess the effects and reveal mechanisms of hypertensive therapeutic treatments, rodent models would be more useful in assisting the interpretation of animal experiments. Also, despite well-known sexual dimorphism in blood pressure regulation, almost all published models are gender neutral. Given these observations, the goal of this project is to develop the first computational models of blood pressure regulation for the male and female rats. The resulting sex-specific models represent the interplay between cardiovascular function, renal hemodynamics, and kidney function in the rat; they also include the actions of the renal sympathetic nerve activity and the renin-angiotensin-aldosterone system, as well as physiological sex differences. We explore mechanisms responsible for blood pressure and renal autoregulation and notable sexual dimorphism. Model simulations suggest that fluid and sodium handling in the kidney of the female rats, which differs ...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research

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Conditions:   Hypertension;   Renal Denervation;   Increased Variability;   Blood Pressure Disorders;   Blood Pressure Variability;   Sympathetic Dysautonomia Intervention:   Device: Renal denervation Sponsor:   St Carlos Hospital, Madrid, Spain Recruiting
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