Ultrasound Brain Stimulation Piloted in Alzheimer Study

Patients with probable Alzheimer disease (AD) had sustained memory improvements 3 months after ultrasound brain stimulation in a small pilot study. The noninvasive technique, called transcranial pulse stimulation (TPS), is designed to apply ultrashort ultrasound pulses to small brain areas.
Source: JAMA - Category: General Medicine Source Type: research

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(University of Virginia Health System) Focused ultrasound, the researchers hope, could revolutionize treatment for conditions from Alzheimer's to epilepsy to brain tumors -- and even help repair the devastating damage caused by stroke.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
The blood–brain barrier (BBB) presents a significant challenge for treating brain disorders. The hippocampus is a key target for novel therapeutics, playing an important role in Alzheimer’s disease (AD), epilepsy, and depression. Preclinical studies have shown that magnetic resonance (MR)-guided low-intensity focused ultrasound (FUS) can reversibly open the BBB and...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Brief Reports Biological Sciences Source Type: research
In conclusion, elevated brain amyloid was associated with family history and APOE ε4 allele but not with multiple other previously reported risk factors for AD. Elevated amyloid was associated with lower test performance results and increased reports of subtle recent declines in daily cognitive function. These results support the hypothesis that elevated amyloid represents an early stage in the Alzheimer's continuum. Blood Metabolites as a Marker of Frailty https://www.fightaging.org/archives/2020/04/blood-metabolites-as-a-marker-of-frailty/ Frailty in older people is usually diagnosed in a sympt...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Iaccarino et al [1] exposed one hour of light flickering at 40 Hz to awake 5XFAD Alzheimer ’s Disease (AD) mouse models, generating action potentials at 40 Hz, activating ∼54% of microglia to colocalize with Aβ plaque, acutely, and clearing ∼ 50% of Aβ plaque after seven days, but only in the visual cortex.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research
Experimental Models of Tauopathy - From Mechanisms to Therapies. Adv Exp Med Biol. 2019;1184:381-391 Authors: Götz JJ, Götz J Abstract Animal models have been instrumental in reproducing key aspects of human tauopathy. In pursuing these efforts, the mouse continues to have a prominent role. In this chapter, we focus on models that overexpress wild-type or mutant forms of tau, the latter being based on mutations found in familial cases of frontotemporal dementia. We review some of these models in more detail and discuss what they have revealed about the underlying pathomechanisms, as well...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Morovic S, Budincevic H, Govori V, Demarin V Abstract Dementia represents one of the greatest global challenges for health and social care in this century. More than 50 million people worldwide suffer from dementia, and this number is predicted to triple by 2050. Ageing is often associated with cognitive impairment. Therefore, prevention of cognitive impairment is an imperative. Dementia includes a heterogeneous group of disorders, the most common being Alzheimer's disease and vascular dementia. Most cardiovascular risk factors such as hypertension, diabetes mellitus, hypercholesterolemia, atrial fibrillat...
Source: Journal of Medicine and Life - Category: General Medicine Tags: J Med Life Source Type: research
Very early research suggests a novel, noninvasive brain stimulation technique guided by ultrasound may improve memory in Alzheimer's disease.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Psychiatry News Source Type: news
Wrapping up this year and looking back on the particularly interesting developments in medical technology, we at Medgadget are impressed and very excited about the future. We’re lucky to cover one of the most innovative fields of research and o...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Source Type: blogs
Publication date: Available online 24 December 2019Source: Journal of Molecular Graphics and ModellingAuthor(s): Marcello Miceli, Stefano Muscat, Umberto Morbiducci, Marco Cavaglià, Marco Agostino DeriuAbstractUltrasound-based technologies are widely adopted in the clinical practice. Recently, the ultrasound stable cavitation has been proposed as a strategy to destabilize amyloid aggregates in Alzheimer disease. However, the molecular mechanisms driving ultrasound-induced amyloid destabilization are not fully clarified yet. Here, molecular dynamics is applied to investigate in silico the conformational dynamics indu...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
Shah Islam Hugh Harvey By HUGH HARVEY, MBBS and SHAH ISLAM, MBBS AI in medical imaging entered the consciousness of radiologists just a few years ago, notably peaking in 2016 when Geoffrey Hinton declared radiologists’ time was up, swiftly followed by the first AI startups booking exhibiting booths at RSNA. Three years on, the sheer number and scale of AI-focussed offerings has gathered significant pace, so much so that this year a decision was made by the RSNA organising committee to move the ever-growing AI showcase to a new space located in the lower level of the North Hall. In some ways it made sense to ...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Artificial Intelligence Health Tech Start-Ups AI Hugh Harvey Radiology RSNA RSNA 2019 RSNA19 Shah Islam Source Type: blogs
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