Effect of Standard Therapy With vs Without an Antistaphylococcal β-Lactam on MRSA Bacteremia Outcomes

This randomized trial compares the effect of combining standard antibiotic therapy (intravenous vancomycin or daptomycin) with an antistaphylococcal β-lactam (intravenous flucloxacillin, cloxacillin, or cefazolin) vs standard therapy alone on a composite outcome of mortality, bacteremia, relapse, or treatment failure in adults with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia.
Source: JAMA - Category: General Medicine Source Type: research

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CONCLUSION: In this review, we present the current approach to the clinical diagnosis and management of osteomyelitis in childhood, with an update on recent recommendations, as a useful instrument to understand the rationale of antibiotic therapy. PMID: 32394145 [PubMed - as supplied by publisher]
Source: World Journal of Pediatrics : WJP - Category: Pediatrics Authors: Tags: World J Pediatr Source Type: research
Conclusions and Relevance: In this study, most patients with community-onset sepsis did not have resistant pathogens, yet broad-spectrum antibiotics were frequently administered. Both inadequate and unnecessarily broad empiric antibiotics were associated with higher mortality. These findings underscore the need for better tests to rapidly identify patients with resistant pathogens and for more judicious use of broad-spectrum antibiotics for empiric sepsis treatment.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Abstract Methicillin-resistant Staphylococcus aureus (MRSA) is one of the dangerous human pathogens and it is categorized as a high priority multi-drug resistant bacterium by WHO. Biofilm forming ability of MRSA is responsible for persistent infections and also difficult to eradicate using antibiotic therapy as biofilm is much more resistant to antibiotics. Thus, targeting biofilm and virulence has become an alternative approach to attenuate the pathogenicity of bacterium without affecting the growth. Hence, the present study was aimed at evaluation of antibiofilm potential of citral against MRSA and to decode the...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
Abstract Methicillin-resistant Staphylococcus aureus (MRSA) is an extensive origin of nosocomial infections that are very much challenging as well as complicated to eradicate mostly due to their strong resistance against all existing antibiotic therapies. Here the chitosan-grafted-polycaprolactone/maleic anhydride-pyrazinamide (CS-g-PCL/MA-PZA) polymeric drug carrier constructed via dialysis for anti-MRSA drugs like rifampicin (RF) and pyrazinamide (PZA) delivery. Nearly 200 nm size of the spherical particle with -20.04 mV of zeta potential observed. The cumulative PZA and RF releases from the carrier were obs...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
CONCLUSION: High anticipation and vigilance is required to detect concurrent bacteremia in dengue patients. Early recognition of warning signs with readily antibiotic therapy is important to prevent mortality and morbidity in these patients. Our report also highlights the MRSA as a rare cause of thyroid abscess with only 5 cases have been reported in the literature so far. PMID: 32164519 [PubMed - as supplied by publisher]
Source: Infectious Disorders Drug Targets - Category: Infectious Diseases Authors: Tags: Infect Disord Drug Targets Source Type: research
This article summarizes the available evidence enabling a stratification of risk for multidrug-resistant bacteria (MDRB) in patients with skin and soft tissue infection (SSTI). Recent findings MDRB are increasingly reported in both healthcare-associated (HCA) and community-acquired (CA)-SSTI, including in patients with life-threatening presentations for whom early initiation of adequate antimicrobial therapy is pivotal to improve outcomes. Community-associated methicillin-resistant Staphylococcus aureus (MRSA) is now endemic in several geographical areas and may cause outbreaks in frail populations or other at-risk clus...
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: SKIN AND SOFT TISSUE INFECTIONS: Edited by Matteo Bassetti Source Type: research
Conclusion. Rapid and accurate detection of S. aureus with the Xpert MRSA/SA BC assay in positive blood culture bottles allowed earlier targeted patient management. Negative Xpert results are suggestive of coagulase negative staphylococci, allowing de-escalation of antimicrobial therapy if clinically appropriate. PMID: 32141812 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research
ConclusionThere was a significant association of antibiotic therapy and age on S. aureus carriage profiles in CF patients indicating that antibiotic therapy prevents acquisition of new clones, while during aging of patients with persisting S. aureus, dominant clones were selected and mutations in the spa-repeat region accumulated.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
This cohort study compares 30-day mortality among adult patients hospitalized for pneumonia receiving empirical anti –methicillin-resistant Staphylococcus aureus (MRSA) therapy vs standard empirical antibiotic regimens.
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
This study aimed to determine whether molecular assays could detect genes encoding carbapenemases, ESBL and MRSA, directly from respiratory samples, so as to expedite appropriate therapy and infection control for patients with BLRTI.MethodsThe CRE, ESBL and MRSA/SA ELITe MGB® assays were performed directly on 354 respiratory specimens sampled from 318 patients admitted with BLRTI. Molecular results were compared to routine culture-based diagnostics results.ResultsPositive (PPV) and negative (NPV) predictive values of the CRE ELITe MGB® kit were 75.9% [IC 95%: 60.3-86.7] and 100%, respectively. PPV and NPV of the ES...
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
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