Risk factors for fecal carriage of drug-resistant Escherichia coli : a systematic review and meta-analysis
ConclusionsThe findings indicate that dietary habit as well as past antimicrobial use and travel to high-risk country are associated with the risk of fecal carriage of drug-resistant commensalE. coli.
Diana Camelia Nuta The increasing threat of antimicrobial resistance to all currently available therapeutic agents has urged the development of novel antimicrobials. In this context, a series of new benzoylthiourea derivatives substituted with one or more fluorine atoms and with the trifluoromethyl group have been tested, synthesized, and characterized by IR, NMR, CHNS and crystal X-ray diffraction. The molecular docking has provided information regarding the binding affinity and the orientation of the new compounds to Escherichia coli DNA gyrase B. The docking score predicted the antimicrobial activity of the studi...
In conclusion, CG analysis defined five new subclades. The ST131 porcine isolates belonged to new subclades B6 and B7. Moreover, porcine and clinical human isolates were strongly related. The 11 porcine ST131 isolates harbored a wide variety of plasmids, virulence, and resistance genes. Furthermore, epidemic plasmids IncX4 and IncHI2 are responsible for the acquisition of mcr-1.1 gene. We hypothesize that the APEC-IncF plasmid acquired the mcr-1.1 gene via cointegrating an IncHI2 plasmid, which is worrying due to combination of virulence and resistance attributes in a single mobile genetic element.
Publication date: Available online 19 March 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Mashkoor Mohsin, Kaori Tanaka, Ryuji Kawahara, Shinji Kondo, Hideki Noguchi, Daisuke Motooka, Shota Nakamura, Diep Thi Khong, Thang Nam Nguyen, Trong Nang Hoang, Yoshimasa Yamamoto
Publication date: Available online 19 March 2020Source: Veterinary MicrobiologyAuthor(s): Kwang Won Seo, Jong Bo Shim, Yeong Bin Kim, Se Hyun Son, Eun Bi Noh, Sunghyun Yoon, Suk-Kyung Lim, Young Ju Lee
Abstract The aim of this article is to report on antimicrobial resistance (AMR) in commensal Escherichia coli from livestock from several European countries. The relationships with antimicrobial usage (AMU) at country level and harmonized indicators to cover the most relevant AMR aspects for human health in animal production were also investigated. E. coli were isolated in faeces from broilers and fattening pigs (from nine countries), and fattening turkeys and veal calves (from three countries) and screened against a fixed antimicrobial panel. AMU data were collected at farm and average treatment incidences strati...
Conclusion. Data produced on the propensity of a molecule to induce bacterial resistance is useful and appropriate when launching a new preservative. PMID: 32186482 [PubMed - as supplied by publisher]
ConclusionExposure of anE. coli isolate to another phagemid-containingE. coli that was treated with propanol-based hand rub increased the development of amoxicillin resistance. Although phagemids are cloning vectors that are not present in clinical isolates, this finding may have implications for hand disinfection practices in healthcare facilities.
Publication date: June 2020Source: Journal of Global Antimicrobial Resistance, Volume 21Author(s): Adesola Olalekan, Francis Onwugamba, Bamidele Iwalokun, Alexander Mellmann, Karsten Becker, Frieder Schaumburg
ConclusionResistance to cefotaxime and the presence of a wide range of beta-lactamase genes exposed the potential risks associated with these pathogens via occupational and domestic exposure during the reuse of treated wastewater.
Abstract Although there has been an increasing incidence of bacteremia caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) across South East Asia, there are sparse data from the Lao PDR, where laboratory capacity for antimicrobial resistance surveillance is limited. We, therefore, retrospectively reviewed bacteremia caused by ESBL-producing Escherichia coli and Klebsiella pneumoniae between 2010 and 2014 at Mahosot Hospital, Vientiane, Lao PDR. Clinical and laboratory data relating to all episodes of ESBL-E bacteremia were reviewed over the 5-year period and compared with non-ES...