Recognizing hypoxia in phaeochromocytomas and paragangliomas

Nature Reviews Endocrinology, Published online: 11 February 2020; doi:10.1038/s41574-020-0324-1Studies uncovering the cellular mechanisms of adaptation to varying oxygen levels were recognized with the 2019 Nobel Prize in Physiology or Medicine. Here, we focus on the remarkable parallels between the pathways regulating oxygen availability and those driving rare neuroendocrine tumours, phaeochromocytomas and paragangliomas, and discuss the translational implications of this connection.
Source: Nature Reviews Endocrinology - Category: Endocrinology Authors: Source Type: research