Multimorbidity and mortality risk in hospitalized adults with chronic inflammatory skin disease in the United States

AbstractChronic inflammatory skin diseases (CISD) represent a significant burden of skin disease in the United States, and a growing number of studies demonstrate that CISD are associated with multiple comorbidities. However, few studies examined multimorbidity in adults with CISD. We sought to determine whether hospitalized US adults with chronic inflammatory skin disorders have increased multi-morbidity and mortality risk. Data from the 2002 –2012 Nationwide Inpatient Sample were analyzed, including a representative 20% sample of US hospitalizations. Charlson comorbidity index (CCI) and mean estimated 10-year survival were calculated. Multivariable linear regression models were constructed with CCI score and mean estimated 10-year sur vival as the dependent variables and chronic inflammatory skin diagnosis, age and sex as the independent variables. CCI scores were significantly higher in bullous pemphigoid (P = 0.0005) and dermatomyositis (P <  0.0001), lower in hidradenitis suppurativa (P <  0.0001), pemphigus (P <  0.0001), rosacea (P <  0.0001), and not significantly different in atopic dermatitis, alopecia areata, and lichen planus compared to psoriasis. Conversely, the mean estimated 10-year survival was higher in pemphigus (P = 0.0451), lichen planus (P = 0.0352), rosacea (P <  0.0001), lower in bullous pemphigoid and dermatomyositis (P <  0.0001), and similar in atopic dermatitis, alopecia areata, and hidradenit...
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research