B Cell-Targeted Immunotherapy Limits Tumor Growth, Enhances Survival, and Prevents Lymph Node Metastasis of UV-Induced Keratinocyte Cancers in Mice
UV-induced DNA damage, suppression of antitumor immune responses, and promotion of cutaneous inflammation underly the skin tumor-promoting activities of sunlight. Targeting the immune regulatory pathways activated by UV is proving to be a highly effective therapeutic strategy in the treatment of both melanoma (Hodi et al., 2010) and keratinocyte cancers (Day et al., 2017). However, many of these first-generation check-point inhibitors come with considerable side effects including an increased risk of autoimmune toxicities (Phan et al., 2003) and rejection of allografts in some transplant recipients at a high risk of metastatic skin cancer (Abdel-Wahab et al., 2019).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Lai-Fong Kok, Angela L. Ferguson, Jacqueline E. Marshall, Benita C.Y. Tse, Gary M. Halliday, Scott N. Byrne Tags: Letters to the Editor Source Type: research
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