Electrocardiographic Effects of Propofol versus Etomidate in Patients with Brugada Syndrome

Conclusions In this trial, there does not appear to be a significant difference in electrocardiographic changes in patients with Brugada syndrome when propofolversus etomidate were administered for induction of anesthesia. This study did not investigate electrocardiographic changes related to propofol used as an infusion for maintenance of anesthesia, so future studies would be warranted before conclusions about safety of propofol infusions in patients with Brugada syndrome can be determined.Editor ’s PerspectiveWhat We Already Know about This TopicBrugada syndrome is an inherited cardiac ion channel disorder that places patients at increased risk of cardiac arrhythmias including those resulting in sudden cardiac death.While there is concern that propofol use may trigger life-threatening ventricular arrhythmias in patients with Brugada syndrome, this has not been assessed using prospective randomized, controlled trials.What This Article Tells Us That Is NewThis study was a prospective randomized double-blind trial that compared groups receiving propofol (n = 43)versus etomidate (n = 37) for induction of general anesthesia. No significant difference in electrocardiographic changes was observed between these two groups.
Source: Anesthesiology - Category: Anesthesiology Source Type: research