The effect of π-Conjugation on the self-assembly of micelles and controlled cargo release.

The effect of π-Conjugation on the self-assembly of micelles and controlled cargo release. Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):525-532 Authors: Liang Y, Sun Y, Fu X, Lin Y, Meng Z, Meng Y, Niu J, Lai Y, Sun Y Abstract Here we presented a novel micelle self-assembled from amphiphiles with π-conjugated moieties (OEG-DPH). The π-conjugated structural integrity of the micelles enabled stable encapsulation of Nile Red (NR, model drug). The self-assembly behaviour of the amphiphiles and the release profile of NR loaded micelles were investigated. Spherical core-shell structured NR loaded micelles with low CMC of 57 μg/mL and the efficient intracellular delivery process was monitored. This research provided a way to fabricate stable polymeric micelles and develop a practical nanocarrier for therapeutics delivery. PMID: 32037890 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research