Transcriptional Regulation of Transforming Growth Factor β1 by Glucose: Investigation into the Role of the Hexosamine Biosynthesis Pathway.
CONCLUSIONS: The metabolism of glucose through the HBP mediates extracellular matrix production, possibly via the stimulation of TGF-β in kidney cells. Hexosamine metabolism therefore, may play a role in the development of diabetic nephropathy.
PMID: 32039769 [PubMed - in process]
Source: The American Journal of the Medical Sciences - Category: General Medicine Authors: Daniels MC, McClain DA, Crook ED Tags: Am J Med Sci Source Type: research
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