Treatment-failure to direct antiviral HCV regimens in real world: frequency, patient characteristics and rescue therapy - data from the  German hepatitis C registry (DHC-R).

CONCLUSIONS:  Patients with failure with DAA combination therapies are a difficult but urgent to treat population with the frequent presence of cirrhosis and prior treatment failure with interferon-based therapies. Rescue therapy with inclusion of a new DAA class leads to high SVR rates, but multiple targeted therapy with VOX/VEL/SOF seems to be most effective.
PMID: 32040979 [PubMed - as supplied by publisher]

Source: Zeitschrift fur Gastroenterologie - February 9, 2020 Category: Gastroenterology Authors: Schmitt A, Günther R, Mauss S, Boeker KHW, Buggisch P, Hillenbrand H, John C, Klinker H, Pathil A, Simon KG, Serfert Y, Niederau C, Vermehren J, Wedemeyer H, Sarrazin C Tags: Z Gastroenterol Source Type: research