Cannabis consumption might exert deleterious effects on sperm nuclear quality in infertile men

ConclusionsCannabis consumption might have deleterious effects on sperm nuclear quality in infertile men by increasing numerical chromosome abnormalities and DNA fragmentation. Cannabis consumption induces these detrimental effects on the progression of spermatogenesis from meiotic stages to spermiogenesis and potentially on post-testicular sperm maturation in infertile men. Any potential findings, however, need to be validated with larger sample size, and our data are only exploratory findings.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research

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In this study, we aimed to evaluate whether the presence of TM has an effect on GCTC prognosis and oncological outcomes. METHODS: Seventy five patients among 93 patients who underwent radical orchidectomy between January 2010 and February 2016 were selected and divided into two groups. Group I consisted of 51 patients without TM. Group II consisted of 24 patients with TM. Each groups were compared in terms of demographic datas, prognostic risk factors, complete blood count parameters and oncological outcomes. RESULTS: During the median follow-up of 58 (1-106) months, a significantly higher local recurrence rate (54.2% vs. 3.9%, p
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research
We present a novel case of azoospermia with a karyotype of 46,Y,t(X:16)(p22.1:p11.2). A 26-year-old, healthy, active duty male Solider presented with his dependent female partner for primary infertility. Female anatomical and endocrine evaluations were normal. Initial male evaluation revealed azoospermia on multiple semen analyses. Further evaluation with a detailed physical exam and laboratory tests were normal except for an abnormal karyotype with a reciprocal translocation at chromosomes X and 16. An open testicular biopsy demonstrated 75% late spermatid maturation arrest confirming reproductive potential although signi...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
AbstractMale infertility is a heterogeneous condition of largely unknown etiology that affects at least 7% of men worldwide. Classical genetic approaches and emerging next-generation sequencing studies support genetic variants as a frequent cause of male infertility. Meanwhile, the barriers to transmission of this disease mean that most individual genetic cases will be rare, but because of the large percentage of the genome required for spermatogenesis, the number of distinct causal mutations is potentially large. Identifying bona fide causes of male infertility thus requires advanced filtering techniques to select for hig...
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
Laparoscopic cholecystectomy is the gold standard surgery for symptomatic gallstones widely done worldwide. Spilled gallstones resulting from gall bladder perforation during specimen retrieval occurs in 20-40% cases [1]. Spillage can occur during gallbladder bed dissection, gallbladder extraction from abdomen or slippage of cystic duct clip from gallbladder side [2].
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Image Article Source Type: research
In this study, the morpho-function of the testes in BXSB/MpJ-Yaa mice was analyzed as a representative mouse model for systemic autoimmune diseases to investigate the effect of excessive autoimmunity on spermatogenesis. At 12 and 24  weeks of age, BXSB/MpJ-Yaa mice showed splenomegaly and increased levels of serum autoantibodies, whereas no controls showed a similar autoimmune condition. In histological analysis, the enlarged lumen of the seminiferous tubules accompanied with scarce spermatozoa in the epididymal ducts were observed in some of the BXSB/MpJ-Yaa and BXSB/MpJ mice but not in C57BL/6N mice. Histoplanimetri...
Source: Cell and Tissue Research - Category: Cytology Source Type: research
Yale Fertility Center physicians explain why postponing treatments is necessary right now.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news
According to a study published in theJournal of the Endocrine Society, a chemical used in hydraulic fracturing may cause disruption to the function of testosterone and increase chances of infertility in men.Science Daily
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
AbstractPurposeTo develop and assess a novel custom next-generation sequencing (NGS) panel for male infertility genetic diagnosis.MethodsA total of 241 subjects with diagnosis of idiopathic infertility ranging from azoospermia to normozoospermia were sequenced by a custom NGS panel includingAR,FSHB,FSHR,KLHL10,NR5A1,NANOS1,SEPT12,SYCP3,TEX11 genes. Variants with minor allele frequency
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
This study aimed to investigate the impact of thyroid hormone on decidualization in human endometrial stromal cells (hESCs) and define its physiological roles in vitro by gene targeting. To identify the expression patterns of thyroid hormone, we performed gene expression profiling of hESCs during decidualization after treating them with the thyroid hormone levothyroxine (LT4). A major increase in decidual response was observed after combined treatment with ovarian steroid hormones and thyroid hormone. Moreover, LT4 treatment also affected the regulation of many transcription factors important for decidualization. We found ...
Source: Endocrinology - Category: Endocrinology Authors: Tags: Endocrinology Source Type: research
This study was aimed at determining the serological markers (IgG, IgM and IgA) of Chlamydia trachomatis, evaluate the association between Chlamydia trachomatis infection and the sociodemographic characteristics and clinical diagnosis of the participants. This was a cross sectional hospital-based study in which blood samples from 145 consenting participants were tested for IgG, IgM and IgA antibodies against Chlamydia trachomatis using enzyme linked immunosorbent assay and their clinical diagnosis, retrieved from their case notes. The cumulative prevalence of seropositivity for Chlamydia trachomatis (IgG, IgM, IgA) was 112 ...
Source: African Journal of Reproductive Health - Category: African Health Tags: Afr J Reprod Health Source Type: research
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