Drug Combo No Better in MRSA Blood Infections, Ups Risk Drug Combo No Better in MRSA Blood Infections, Ups Risk

Adding a beta-lactam to standard therapy for MRSA bacteremia does not improve outcomes and appears to up the risk for kidney injury, data from a randomized controlled trial showed.Medscape Medical News
Source: Medscape Internal Medicine Headlines - Category: Internal Medicine Tags: Infectious Diseases News Source Type: news

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ConclusionFree floating thrombus of the carotid arteries can be managed with stenting.
Source: Clinical Neuroradiology - Category: Neurology Source Type: research
Planta Med DOI: 10.1055/a-1130-4856Recently, the isolation and elucidation of a series of polyhydroxyanthraquinones were reported from an organic extract of a solid phase culture of an endophytic fungus, Penicillium restrictum (strain G85). One of these compounds, ω-hydroxyemodin (1), showed promising quorum-sensing inhibition against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) in both in vitro and in vivo models. The initial supply of 1 was 19 mg, and this amount needed to be scaled by a factor of 30 to 50 times, in order to generate material for further in vivo studies. To do so, ...
Source: Planta Medica - Category: Drugs & Pharmacology Authors: Tags: Original Papers Source Type: research
Abstract Staphylococcus aureus is the most common pathogen involved in skin infections worldwide, regardless of the patient's age, the climate or geographical area. The main skin clinical manifestations can be linked to a few toxins produced by the bacteria, which give rise to a rich and varied clinical spectrum. Panton Valentine leucocidin, exfoliatins, enterotoxins and toxin shock syndrome toxin 1 are the main toxins involved in most dermatological manifestations associated with S. aureus. Other less frequent cutaneous manifestations can occur in endocarditis, bacteraemia or related to a contiguity focus. Curren...
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research
Publication date: Available online 22 March 2020Source: Clinical Epidemiology and Global HealthAuthor(s): Hadi Safdari, Ehsan Aryan, Hamid Sadeghian, Seyyedeh Fatemeh Shams, Mahdi Aganj
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
This study shows that phosphonopeptides, including alafosfalin, may have a therapeutic role to play in an era of increasing antibacterial resistance.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
This study focuses on estimating the prevalence of MRSA in shrines, a place where human and animal interaction is frequent, sharing antibiotic-resistant bacteria, antibiotic-resistant genes, and diseases. A total of 120 environmental swabs were collected from targeted areas during the study period, March 2018 to May 2018. Staphylococcus aureus was identified by growth on mannitol salt agar (MSA), and MRSA by growth on mannitol salt agar containing 4 μg Oxacillin, Gram staining, and conventional biochemical test. Isolates of S. aureus were characterized by antibiotic susceptibility testing using the disc diffusion...
Source: International Journal of Microbiology - Category: Microbiology Tags: Int J Microbiol Source Type: research
To analyze the clinical characteristics, management choices, and outcomes of cases of methicillin-resistant Staphylococcal aureus (MRSA) keratitis.
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Original Articles Source Type: research
Condition:   MRSA Intervention:   Other: none intervention Sponsor:   Sir Run Run Shaw Hospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This article advocates for a new metric by suggesting criteria to construct it, in order to provide a “value-based” measurement for CA-MRSA as a starting point for all infectious diseases. It also discusses challenges to this suggested approach.
Source: Archives of Public Health - Category: International Medicine & Public Health Source Type: research
Abstract Antimicrobial peptides (AMP) with anticancer activity have drawn remarkable attention in modern treatments. However, long peptide length and protease instability are the most addressing factors, which hampers their further development as therapeutic agents. In view of this, herein, we designed and synthesized a series of AZT-based cationic small molecule incorporating a variety of hydrophobic groups and cationic charges, including amine and guanidine groups to mimic the amphipathic structure of AMPs. These compounds were evaluated for their antibacterial activity against Gram-positive and Gram-negative ba...
Source: European Journal of Medicinal Chemistry - Category: Chemistry Authors: Tags: Eur J Med Chem Source Type: research
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