Positron emission tomography (PET) radiotracers for prostate cancer imaging

AbstractImaging plays an increasing role in prostate cancer diagnosis and staging. Accurate staging of prostate cancer is required for optimal treatment planning. In detecting extraprostatic cancer and sites of early recurrence, traditional imaging methods (computed tomography, magnetic resonance imaging, radionuclide bone scan) have suboptimal performance. This leaves a gap between known disease recurrence as indicated by rising prostate-specific antigen and the ability to localize the recurrence on imaging. Novel positron emission tomography (PET) agents including radiolabeled choline, fluciclovine (18F-FACBC), and agents targeting prostate-specific membrane antigen are being developed and tested to increase diagnostic performance of non-invasive prostate cancer localization. When combined with CT or MRI, these tracers offer a combination of functional information and anatomic localization that is superior to conventional imaging methods. These PET radiotracers have varying mechanisms and excretion patterns affecting their pharmacokinetics and diagnostic performance, which will be reviewed in this article.
Source: Abdominal Imaging - Category: Radiology Source Type: research

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Source: BMC Medical Imaging - Category: Radiology Authors: Tags: Research article Source Type: research
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Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
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Source: Topics in Magnetic Resonance Imaging - Category: Radiology Tags: Review Articles Source Type: research
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Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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Source: Medicine - Category: Internal Medicine Authors: Tags: Common cancers Source Type: research
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Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
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Source: Canadian Urological Association Journal - Category: Urology & Nephrology Authors: Tags: Can Urol Assoc J Source Type: research
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Source: Molecular Imaging - Category: Radiology Tags: Mol Imaging Source Type: research
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Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
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Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
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