A systematic review on concurrent aneuploidy screening and preimplantation genetic testing for hereditary disorders: what is the prevalence of aneuploidy and is there a clinical effect from aneuploidy screening?

ConclusionOn average aneuploidy is detected in 34 % of embryos when performing a single blastocyst biopsy derived from patients carrying or affected by an inherited disorder. Accordingly, when screening for aneuploidy, the risk of experiencing a cycle with no transferable embryos increases. Current available data on the clinical effect of preimplantation genetic testing for aneuploidy performed concurrently with preimplantation genetic testing for inherited disorders is sparse, rendering the clinical effect from preimplantation genetic testing for aneuploidy difficult to access.

Source: Acta Obstetricia et Gynecologica Scandinavica - February 11, 2020 Category: OBGYN Authors: Christian Liebst Frisk Toft, Hans Jakob Ingerslev, Ulrik Schi øler Kesmodel, Tue Diemer, Birte Degn, Anja Ernst, Henrik Okkels, Kristín Rós Kjartansdóttir, Inge Søkilde Pedersen Tags: SYSTEMATIC REVIEW Source Type: research