Word retrieval across the biomarker-confirmed Alzheimer's disease syndromic spectrum

Publication date: Available online 10 February 2020Source: NeuropsychologiaAuthor(s): Deepti Putcha, Bradford C. Dickerson, Michael Brickhouse, Keith A. Johnson, Reisa A. Sperling, Kathryn V. PappAbstractAlzheimer's disease (AD) is now conceptualized as a biological entity defined by amyloid and tau deposition and neurodegeneration, with heterogeneous clinical presentations. With the aid of in vivo biomarkers, clinicians are better poised to examine clinical syndromic variability arising from a common pathology. Word retrieval deficits, measured using verbal fluency and confrontation naming tests, are hallmark features of the early clinical stages of the amnestic presentations of AD, specifically in category fluency and naming with relatively spared letter fluency. As yet, there is no consensus regarding performance on these tests in atypical clinical phenotypes of AD, including posterior cortical atrophy (PCA) and logopenic primary progressive aphasia (lvPPA), in individuals who are amyloid-positive (Aβ+) but present with different clinical profiles and patterns of neurodegeneration compared to amnestic AD. The goal of the current study is to determine how Aβ+ individuals across the syndromic spectrum of AD perform on three different word retrieval tasks. A secondary goal is to determine the neuroanatomical substrates underlying word retrieval performance in these Aβ+ individuals. Thirty-two Aβ+ participants with the amnestic presentation, 16 with Aβ...
Source: Neuropsychologia - Category: Neurology Source Type: research

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CONCLUSIONS: Brain 18F-FDG PET had an elevated performance in the early diagnosis of PPA variants and in the advanced PPA AD/FTD classification. QL clarified the development of AD or FTD in advanced PPA cases and supported the differential diagnosis of a PPA variant in a few early cases. QN 18F-FDG PET evaluation better contributed to the early diagnosis of an unclear metabolic pattern. To correctly identify all cases, patients with diffuse cortical hypometabolism were also included. Larger series are necessary to confirm these data. PMID: 32062656 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
Conclusion: Tau accumulation likely started in the more affected anterior node and, at the disease stage at which we studied these patients, appeared as well in the brain region (in the temporal lobe) spatially separate from but most connected with it. The arcuate fasciculus, connecting both of them, was most severely affected anteriorly, as would correspond to a loss of axons from the anterior node. These findings are suggestive of tau propagation from node to connected node in a natural human brain network and support the idea that neurons that wire together die together.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Clinical Source Type: research
DISCUSSION: The global CDR plus NACC FTLD score could be an attractive outcome measure for clinical trials in symptomatic FTLD, and may be useful in natural history studies and clinical trials in FTLD spectrum disorders. PMID: 31914218 [PubMed - in process]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Can you distinguish the taste of a red wine versus a rosé? How about the look of a 1960s muscle car versus a foreign import? Do you prefer to grow lilies or tulips? Would you rather listen to Dark Side of the Moon or “Fly Me to the Moon”? To answer any of these questions, you need to use your semantic memory. Your semantic memory is your store of factual knowledge of the world and the meaning of words. It’s how you know that a fork is for eating (not twirling your hair) and what color a lion is. It’s both the source of your vocabulary and how you know what something does even if you don&rsquo...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Alzheimer's Disease Brain and cognitive health Healthy Aging Memory Source Type: blogs
CONCLUSIONS: The TDQ-30 has the potential to become a valuable picture-naming test for the diagnosis of mild anomia associated with pathological aging. PMID: 31792492 [PubMed - as supplied by publisher]
Source: Archives of Clinical Neuropsychology - Category: Psychiatry & Psychology Authors: Tags: Arch Clin Neuropsychol Source Type: research
AbstractThe diagnostic workflow of patients with cognitive decline needs an extensive clinical evaluation. The use of FDG-PET can be helpful because the finding of a rather specific pattern of hypometabolism could point to specific neurodegenerative disorders. In patients with memory impairment and visuo-spatial deficits, FDG-PET may reveal a pattern of temporo-parietal hypometabolism that is associated with Alzheimer ’s disease or a more extended area of hypometabolism that spreads to the occipital cortex, as in posterior cortical atrophy indicating signs of neurodegeneration in the associative visual cortex. In the...
Source: Clinical and Translational Imaging - Category: Radiology Source Type: research
Abstract Primary progressive aphasia (PPA) is a progressive neurodegenerative disease that disrupts the language capacity of an individual by selectively affecting the language network of brain. Although aphasic literature is replete with reports of brain damage responsible for various types of PPA, it does not provide a comprehensive understanding of whether PPA is an independent pathological condition or an atypical syndrome of neurodegenerative diseases (NDD). To address this ambiguity, we provide a detailed description of PPA, its variants and their brain anatomy. Subsequently, we unravel the relationship betw...
Source: Journal of Genetics - Category: Genetics & Stem Cells Authors: Tags: J Genet Source Type: research
Conditions:   Alzheimer Disease, Early Onset;   Atypical Alzheimer's Disease;   Logopenic Progressive Aphasia Interventions:   Device: Anodal tDCS;   Device: Sham;   Other: Word list learning therapy Sponsor:   Johns Hopkins University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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