Serial evaluation of cardiac biomarker NT-proBNP with speckle tracking echocardiography in a 6-year-old Golden Retriever dog with subaortic stenosis and dilated cardiomyopathy.

Serial evaluation of cardiac biomarker NT-proBNP with speckle tracking echocardiography in a 6-year-old Golden Retriever dog with subaortic stenosis and dilated cardiomyopathy. Vet Q. 2020 Feb 08;:1-10 Authors: Ro WB, Kang MH, Park HM Abstract A 6-year-old 37.5-kg Golden Retriever dog was presented with intermittent coughing and cardiac murmur. The dog was diagnosed with subaortic stenosis (SAS) and dilated cardiomyopathy (DCM). The serum N-terminal pro B-type natriuretic peptide (NT-proBNP) concentration, conventional echocardiography, and two-dimensional speckle tracking echocardiography (2D-STE) were serially evaluated for 6 months. At admission, the dog showed a significant increase in the serum NT-proBNP concentration and severe reduction in the 2D-STE strain values. During the monitoring period, the 2D-STE was capable of detecting segmental dyskinesia in apical region, even though the concentration of NT-proBNP in serum was decreased. In addition, longitudinal deformations most sensitively indicated the myocardial damage, while radial and circumferential deformations accurately indicated myocardial contractility. This is the first case report of a dog with SAS and DCM, which demonstrated and compared serial changes of NT-proBNP and 2D-STE with disease progression. In this case, the combined use of NT-proBNP with 2D-STE showed excellent diagnostic and prognostic utility in investigating myocardial injury. PMID: 32036775 ...
Source: Veterinary Quarterly - Category: Veterinary Research Tags: Vet Q Source Type: research