β-Elemene Inhibits the Metastasis of Multidrug-Resistant Gastric Cancer Cells Through miR-1323/Cbl-b/EGFR Pathway

Conclusion: Our results suggested that β-Elemene inhibits the metastasis of MDR gastric cancer cells by modulating the miR-1323/Cbl-b/EGFR signaling axis.Graphical abstracts
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research

Related Links:

Authors: Pappas-Gogos G, Baltagiannis EG, Kyrochristos ID, Ziogas DE, Goussia A, Mitsis M, Roukos DH PMID: 32250157 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
Authors: Nazemalhosseini-Mojarad E, Sanjabi F, Babini H PMID: 32250155 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
Conclusion: The mSHOX2/mPTGER4 assay showed some values with more limitations in lung cancer early detection. PMID: 32250153 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
The Southern Spectroscopic Survey Telescope (SSST) is a planned multi-wavelength space survey telescope by China located in Chile. In this ...
Source: Applied Optics - Category: Physics Authors: Source Type: research
Boris Johnson still in intensive care; Chinese city of Wuhan officially reopens; cases in Africa pass 10,000. Follow the latest updates.Boris Johnson ‘stable’ in intensive care and not on ventilator, says No 10Australia coronavirus updates – liveAt a glance: latest developmentsSee all of our coronavirus coverage5.16amBSTI ’m close to being this insanepic.twitter.com/6qAc8YjvUA5.11amBSTSarah Boseley speaks toProf Trudie Lang about the outbreak on the continent and explores how a history of responding toEbola and other public health emergencies could help.Related:Covid-19: how are African countries co...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news Europe UK news US news Africa Middle East and North Africa Asia Pacific Infectious diseases Science Source Type: news
Authors: Darzi S, Mirzaei SA, Elahian F, Shirian S, Peymani A, Rahmani B, Dibazar SP, Aali E Abstract The capability of flavonoids in sensitizing cancer cells was demonstrated in numerous works to chemotherapy and converse multidrug resistance by modulating efflux pumps and apoptosis mechanisms. Three flavonoids, namely, bavachinin, tephrosin, and candidone, have been recently introduced to cancer treatment research presenting various activities, such as antibacterial, immunomodulatory, cell death, and anticancer. Less information exists regarding the therapeutic significance of these flavonoids in cancer treatment...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
In conclusion, e-As4S4 holds great potential for an alternative therapeutics in the treatment of breast cancer, due to its unique function of correcting the aggressive microenvironment. Introduction Metastasis is the leading cause of breast cancer mortality, which has been one major challenge in clinical treatment (1). In particular, triple-negative breast cancer (TNBC) is characterized by the absence of estrogen receptors (ER), progesterone receptors (PR) and HER2 receptors, which is one of the most aggressive types of breast cancers, marked by high rates of relapse, visceral metastases and early death (2, 3). The...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Discussion Suppressor of cytokine signaling 1 is an essential molecule for maintaining immune homeostasis and subverting inflammation. Disorders arising from excess inflammation or SOCS1 deficiency can be potentially treated with SOCS1 mimetics (Ahmed et al., 2015). While SOCS1 has promising potential in many disorders, it should be noted that new targets and actions of SOCS1 are still being discovered and not all the effects of this protein are beneficial in autoimmune diseases and cancer. For instance, SOCS1 degrades IRS1 and IRS2, required for insulin signaling, via the SOCS Box domain, thus, limiting its potential in ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In conclusion, osmotic burst of inflated complement-damaged cells may occur, but these bursts are most likely a consequence of metabolic collapse of the cell rather than the cause of cell death. The Complement Cell Death Mediator: A Concerted Action of Toxic Moieties Membrane pores caused by complement were first visualized by electron microscopy on red blood cell membranes as large ring structures (22). Similar lesions were viewed on E. coli cell walls (23). Over the years, ample information on the fine ultrastructure of the MAC that can activate cell death has been gathered (24) and has been recently further examined (...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
More News: Breast Cancer | Cancer | Cancer & Oncology | China Health | Complementary Medicine | Drugs & Pharmacology | Epithelial Cancer | Gastric (Stomach) Cancer | Gastroenterology | Herbs | Multidrug Resistance | Study