Epidermal damage induces Th1 polarization and defines the site of inflammation in murine epidermolysis bullosa acquisita

In this study, using the immunization-induced mouse model of EBA, we demonstrate that epidermal disruption induces not only an infiltration of CD4+ T cells but also a Th1 phenotype as it has been described for delayed-type hypersensitivity reactions.

Source: Journal of Investigative Dermatology - February 9, 2020 Category: Dermatology Authors: Markus Niebuhr, Katja Bieber, David Banczyk, Sebastian Maass, Sebastian Klein, Mareike Becker, Ralf Ludwig, Detlef Zillikens, J ürgen Westermann, Kathrin Kalies Tags: Original Article Source Type: research