LINE-1 retrotransposon encoded ORF1p expression and promoter methylation in oral squamous cell carcinoma: a pilot study
Oral squamous cell carcinoma (OSCC) is highly predominant in India due to excessive use of tobacco. Here we investigated Long INterpersed Element 1 (LINE or L1) retrotransposon activity in OSCC samples in the same population. There are almost 500,000 copies of L1 occupied around 30% of the human genome. Although most of them are inactive, around 150-200 copies are actively jumping in a human genome. L1 encodes two proteins designated as ORF1p and ORF2p and expression of both proteins are critical for the process of retrotransposition.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Savita Budania, Debpali Sur, Jitendra Nangal, Sofia Pilli, Koel Mukherjee, Manash Biswas, Ramasare Prasad, Prabhat K. Mandal, Shilpi Saxena Source Type: research
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