Airway profile of bioactive lipids predicts early progression of lung disease in cystic fibrosis

Progressive lung disease characterized by airway obstruction, bacterial infection, and inflammation is the main cause of morbidity in cystic fibrosis (CF) patients. Structural lung anomalies are readily detected by chest computed tomography (CT) in CF infants within a few months of birth [1]. Mucus obstruction and bacterial infections are not the sole causes of inflammation in early CF lung disease. Indeed, knockout of the CF transmembrane conductance regulator (CFTR) is sufficient to cause inflammatory lung disease in ferrets, even in the absence of bacterial infection [2].

Source: Journal of Cystic Fibrosis - February 9, 2020 Category: Respiratory Medicine Authors: Hamed Horati, Hettie M. Janssens, Camilla Margaroli, Mieke Veltman, Marta Stolarczyk, Matthew B. Kilgore, Jeffrey Chou, Limin Peng, Harm A.M.W. Tiddens, Joshua D. Chandler, Rabindra Tirouvanziam, Bob J. Scholte Tags: Original Article Source Type: research