Gyriform restricted diffusion in adults: looking beyond thrombo-occlusions

AbstractGyriform restricted diffusion (GRD) refers to hyperintense signal involving the cerebral cortex on diffusion-weighted images (DWI) with corresponding hypointensity on apparent diffusion coefficient (ADC) images. These changes are commonly seen following a vascular occlusion, reflecting the limitation of water molecule movement across cell membranes (restricted diffusion) due to the failure of Na+/K+-ATPase pumps (cytotoxic oedema). However, GRD can occur in several other neurological conditions as well. A thorough understanding of these conditions and their anatomic predilection plays a critical role in identifying and differentiating them from vascular thrombo-occlusion, with impact towards appropriate clinical management. This review highlights the less commonly encountered, non-stroke causes of GRD in adults with case-based examples. A tabulated chart of the patterns of cortical and subcortical involvement associated with these aetiologies is provided for a quick, pattern-based reference for daily radiological reporting.
Source: Insights into Imaging - Category: Radiology Source Type: research

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Authors: PMID: 32463635 [PubMed - as supplied by publisher]
Source: American Family Physician - Category: Primary Care Tags: Am Fam Physician Source Type: research
Publication date: Available online 28 May 2020Source: American Journal of Kidney DiseasesAuthor(s): James B. Wetmore, Charles A. Herzog, Anne Sexter, David T. Gilbertson, Jiannong Liu, Scott E. Kasner
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Conditions:   Stroke, Ischemic;   Coronary Artery Disease;   Angina Pectoris, Stable;   Diabetic Peripheral Neuropathy Interventions:   Drug: Buqitongluo Granule;   Drug: Buqitongluo Granule Placebo;   Other: Standard care Sponsors:   Dongzhimen Hospital, Beijing;   The Affiliated Hospital of Changchun University of Chinese Medicine;   The Affiliated Hospital of Shandong University of Chinese Medicine;   The Affiliated Hospital of Chengdu University of Chinese Medicine;   The Second Af...
Source: - Category: Research Source Type: clinical trials
Condition:   Stress Hyperglycemia and Stroke Intervention:   Other: standard protocol for stroke patients Sponsor:   Ain Shams University Completed
Source: - Category: Research Source Type: clinical trials
Conclusions: Rise in AIx within one week after ischaemic stroke may be of additional importance in determining better early and late favourable functional outcome. PMID: 32456469 [PubMed - as supplied by publisher]
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
The human connectome reflects the agenda for the new era of brain networks.1 The connectome represents the structural and functional layout of brain networks and often is represented as a mathematical grid.2-4 Brain network graphs provide a simplified view of the human brain connectome, using graph theory to abstractly define the brain as a set of anatomical regions (or “nodes”) and structural connections (called “edges”).4,5
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Supplement Source Type: research
This study analyzed if the variation between TT genotype and the other genotypes (CT and CC), in -589 (rs2243250) polymorphism of IL4 gene, has association with the prognosis of hemorrhagic stroke (HS) and with clinical aspects which are risk factors for cerebrovascular diseases. The result of this study shows that there is no statistical association of the IL4 polymorphism with either prognosis or clinical aspects in HS patients.RESUMEN La interleucina-4 (IL-4) tiene gran importancia en los procesos inflamatorios en casos de accidente cerebrovascular (ACV), puesto que hace que las microgl ías sean polarizadas hacia...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research
BACKGROUND Blunt cerebrovascular injuries (BCVI) can significantly impact morbidity and mortality if undetected and, therefore, untreated. Two diagnostic concepts are standard practice in major trauma management: Application of clinical screening criteria (CSC) does or does not recommend consecutive computed tomography angiography (CTA) of head and neck. In contrast, liberal CTA usage integrates into diagnostic protocols for suspected major trauma. First, this study's objective is to assess diagnostic accuracy of different CSC for BCVI in a population of patients diagnosed with BCVI after the use of liberal CTA. Second, ...
Source: The Journal of Trauma: Injury, Infection, and Critical Care - Category: Orthopaedics Tags: ORIGINAL ARTICLES Source Type: research
BACKGROUND Patients with blunt cerebrovascular injuries are at risk of thromboembolic stroke. Although primary prevention with antithrombotic therapy is widely used in this setting, its effectiveness is not well defined and requires further investigation. The aim of this study was to evaluate the utility of magnetic resonance imaging (MRI)–detected ischemic brain lesions as a possible future outcome for randomized clinical trials in this patient population. METHODS This prospective observational study included 20 adult blunt trauma patients admitted to a level I trauma center with a screening neck CTA showing ex...
Source: The Journal of Trauma: Injury, Infection, and Critical Care - Category: Orthopaedics Tags: ORIGINAL ARTICLES Source Type: research
BACKGROUND Blunt cerebrovascular injuries (BCVIs) are associated with significant morbidity and mortality. This guideline evaluates several aspects of BCVI diagnosis and management including the role of screening protocols, criteria for screening cervical spine injuries, and the use of antithrombotic therapy (ATT) and endovascular stents. METHODS Using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology, a taskforce of the Practice Management Guidelines Committee of the Eastern Association for the Surgery of Trauma performed a systematic review and meta-analysis of currently avail...
Source: The Journal of Trauma: Injury, Infection, and Critical Care - Category: Orthopaedics Tags: GUIDELINES Source Type: research
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