Visual tests predict dementia risk in Parkinson disease

Objective To assess the role of visual measures and retinal volume to predict the risk of Parkinson disease (PD) dementia. Methods In this cohort study, we collected visual, cognitive, and motor data in people with PD. Participants underwent ophthalmic examination, retinal imaging using optical coherence tomography, and visual assessment including acuity and contrast sensitivity and high-level visuoperception measures of skew tolerance and biological motion. We assessed the risk of PD dementia using a recently described algorithm that combines age at onset, sex, depression, motor scores, and baseline cognition. Results One hundred forty-six people were included in the study (112 with PD and 34 age-matched controls). The mean disease duration was 4.1 (±2·5) years. None of these participants had dementia. Higher risk of dementia was associated with poorer performance in visual measures (acuity: = 0.29, p = 0.0024; contrast sensitivity: = –0.37, p
Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: Parkinson's disease/Parkinsonism, Retina, Visual processing, Parkinson's disease with dementia Research Source Type: research

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