Impact of brain atrophy on tDCS and HD-tDCS current flow: a modeling study in three variants of primary progressive aphasia
ConclusionLimited to the conditions and assumptions considered here, this argues against a specific need to adjust the tDCS montage for these patients any more than might be considered useful in anatomically typical adults. Therefore, local atrophy does not, in isolation, reliably predict local electric field. Rather, our results are consistent with holistic head anatomy influencing brain current flow, with tDCS producing diffuse and individualized brain current flow patterns and HD-tDCS producing targeted brain current flow across individuals.
Discussion Memory is an important part of what distinguishes higher order species from others. Memory also is part of one’s self-identity. Difficulties in short-term memory can make common, everyday tasks difficult for the person experiencing the problem particularly if it recently occurred and the person’s long-term memory is intact. Difficulties with long-term memory can also have problems when language, events or even one’s own identity are affected. For some people the memory loss is temporary but for others, memory impairments are permanent and must be accepted and accommodated as part of the overall...
Conclusion Various skull base tumors involving MCF with extension to adjacent sites can be successfully resected using the TZ-MCF approach in a multidisciplinary fashion. This approach yields optimal exposure and permits excellent tumor control with acceptable CN and neurological morbidity. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text
Publication date: Available online 25 March 2020Source: Brain StimulationAuthor(s): Noah S. Philip, Nicole CR. McLaughlin, Linda L. Carpenter, Mary L. Phillips, Hesheng Liu, Suzanne N. Haber, Benjamin D. Greenberg
CONCLUSIONS: This is the first observation of SD occurring after cSDH evacuation. SD occurred at a rate of 15% and was associated with neurological deterioration. This may represent a novel mechanism for otherwise unexplained fluctuating neurological deficit after cSDH evacuation. This could provide a new therapeutic target, and SD-targeted therapies should be evaluated in prospective clinical trials. PMID: 32217801 [PubMed - as supplied by publisher]
Theta burst stimulation (TBS) is a novel form of transcranial magnetic stimulation that rapidly alters synaptic plasticity (1). During TBS, short bursts of high-frequency (typically 50 Hz) stimulation are repeated at 5 Hz (200 ms interval). When TBS is delivered in trains separated by rest periods (intermittent; iTBS) it has shown long-term potentiation-like effects on cortical neurons. In the last several years, numerous reports have indicated that repeated applications of iTBS have efficacy to reduce symptoms of major depressive disorder (2).
Conditions: Post-stroke Depression; Post-stroke Aphasia Interventions: Behavioral: Intensive communicative-pragmatic social interaction.; Behavioral: Standard care. Sponsor: University Medicine Greifswald Recruiting
We describe, for the first time, a case of developmental dynamic dysphasia (DDD) in a right-handed adolescent boy (subject D) with cortical malformations involving language-eloquent regions (inferior frontal gyrus) in both the left and the right hemispheres. Language evaluation revealed a markedly reduced verbal output affecting phonemic and semantic fluency, phrase and sentence generation and verbal communication in everyday life. Auditory comprehension, repetition, naming, reading and spelling were relatively preserved, but executive function was impaired. Multimodal neuroimaging showed a malformed cerebral cortex with a...
Abstract Aphasic discourse has been investigated through two major approaches: a micro-linguistic approach and a macro one, but the separate analysis of the micro and macro aspects of aphasic discourse has led to a noticeable gap between them. Cohesion analysis is one of the possible ways that can directly connect these two aspects. However, few studies have investigated cohesion in aphasic discourse in an integrated manner. The present study employs a mixed-methods approach to examine whether and how patients with fluent and non-fluent stroke-induced aphasia differ from normal individuals in the cohesion of their...
Publication date: August 2020Source: Journal of Neurolinguistics, Volume 55Author(s): Anastasios M. Georgiou, Ioannis Phinikettos, Chrysa Giasafaki, Maria Kambanaros