RhoA and RhoC differentially modulate estrogen receptor α recruitment, transcriptional activities, and expression in breast cancer cells (MCF-7).

CONCLUSIONS: Taken together, our results strongly suggest that RhoA and RhoC play different, but clear, roles in ERα signaling. These GTPases are definitely involved, along with RhoB, in ERα recruitment and, to some extent, ERα cofactor balance. We hypothesize a differential role of RhoA in breast cancer tumors that depend on hormone status. PMID: 24096540 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/24096540?dopt=Abstract

Source: Clinical Breast Cancer - October 6, 2013 Category: Cancer & Oncology Authors: Malissein E, Meunier E, Lajoie-Mazenc I, Médale-Giamarchi C, Dalenc F, Doisneau-Sixou SF Tags: J Cancer Res Clin Oncol Source Type: research