ATP-citrate lyase epigenetically potentiates oxidative phosphorylation to promote melanoma growth and adaptive resistance to MAPK inhibition.

CONCLUSIONS: We demonstrate that ACLY epigenetically potentiates oxidative phosphorylation to promote melanoma growth and MAPK inhibition adaptive resistance. Our study discovers the novel crosstalk between lipogenesis and mitochondrial function in tumor biology, and highlights targeting ACLY as a potent therapeutic approach via simultaneously impairing tumor growth and MAPK inhibition resistance in melanoma. PMID: 32034077 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32034077?dopt=Abstract

Source: Clinical Cancer Research - February 6, 2020 Category: Cancer & Oncology Authors: Li C, Guo W, Ma J, Yang Y, Guo S, Zhang W, Zhao T, Yi X, Wang H, Wang S, Liu Y, Dai W, Chen X, Shi Q, Wang G, Gao T Tags: Clin Cancer Res Source Type: research