Proteomic and Metabolite Profiling Reveals Profound Structural and Metabolic Reorganization of Adipocyte Mitochondria in Obesity.

CONCLUSIONS: Protein components of the OXPHOS machinery are systematically downregulated in adipose tissues of DIO mice compared with lean mice. Loss of the mitochondrial OXPHOS capacity in adipocytes may aggravate the development of metabolic disease.
PMID: 32034895 [PubMed - as supplied by publisher]

Source: Obesity - February 6, 2020 Category: Eating Disorders & Weight Management Authors: Schöttl T, Pachl F, Giesbertz P, Daniel H, Kuster B, Fromme T, Klingenspor M Tags: Obesity (Silver Spring) Source Type: research