Synthetic studies towards (–)-deserpidine: Total synthesis of the stereoisomer and derivative of (–)-deserpidine

Publication date: Available online 8 February 2020Source: Chinese Chemical LettersAuthor(s): Pingzhou Wu, Qilong Zhou, Xiao-Yu Liu, Fei Xue, Yong QinAbstractThe asymmetric synthesis of 16,17,20-epi-deserpidine and a derivative of (–)-deserpidine has been achieved. Key featuresin the assembly of the pentacyclic framework include a visible-light photocatalytic intra-/inter-/intramolecular radical cascade reaction to construct the tetracyclic ABCD ring system in one-pot and an intramolecularaldol reaction to forge the cyclohexane E ring.Graphical AbstractThe asymmetric synthesis of 16,17,20-epi-deserpidine and a lactone derivative of (–)-deserpidine has been achieved. Key steps for constructing the pentacyclic core skeleton include a visible-light photocatalytic intra-/inter-/intramolecular radical cascade reaction and an intramolecularaldol reaction.
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research