Acute Liver Failure of Non–A-E Etiology—Profile, Prognosis, and Predictors of Outcome

Publication date: Available online 16 January 2020Source: Journal of Clinical and Experimental HepatologyAuthor(s): Shalimar, Subrat K. Acharya, Ramesh Kumar, Gangadhar Bharath, Gyanranjan Rout, Deepak Gunjan, Baibaswata NayakBackground/objectivesAcute liver failure (ALF) is rare and associated with poor outcomes. The outcomes of ALF and predictors of outcome may vary as per the etiology. There are limited data on the predictors of spontaneous survival among patients with ALF of non–A-E hepatitis or cryptogenic etiology. We aimed to assess clinical course, complications, and outcome of non–A-E etiology ALF.MethodsIn this prospective analysis, all consecutive ALF patients (n = 1555; January 1986–June 2018) were analyzed. Non–A-E-ALF was defined as ALF that could not be attributed to known etiologies such as drugs, viral hepatitis, autoimmune hepatitis, and Wilson's disease. Clinical course, complications, and outcomes of non–A-E-ALF patients who did not undergo liver transplantation were analyzed. Unadjusted and adjusted odds ratios (ORs) were calculated.ResultsNon–A-E-ALF constituted 34.6% (n = 538) of all ALF patients, whereas hepatitis E virus (HEV), hepatitis B virus (HBV), and anti-tuberculosis therapy (ATT) accounted for 29.5% (n = 459), 8.6% (n = 134), and 7.4% (n = 115), respectively. Among non–A-E-ALF patients, mean age was 28.8 ± 12.0 years, 50.9% females, majority (63.1%) had hyperac...
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research

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More News: Autoimmune Disease | Gastroenterology | Hepatitis | Hepatitis B | Liver | Liver Transplant | Transplants | Tuberculosis | Urology & Nephrology | Wilson's Disease