3-methyladenine inhibits procollagen-1 and fibronectin expression in dermal fibroblasts independent of autophagy.
CONCLUSION: We revealed that 3-MA might inhibit procollagen-1 and fibronectin synthesis in an autophagy-independent manner by interfering with the binding between Smad3 and p300. Therefore, 3-MA could be a candidate for the treatment of diseases associated with the accumulation of ECM proteins.
PMID: 32031067 [PubMed - as supplied by publisher]
Source: Current Molecular Medicine - Category: Molecular Biology Authors: Jung JY, Choi H, Son ED, Kim HJ Tags: Curr Mol Med Source Type: research