Gut Microbiome of a Porcine Model of Metabolic Syndrome and HF-pEF.

Gut Microbiome of a Porcine Model of Metabolic Syndrome and HF-pEF. Am J Physiol Heart Circ Physiol. 2020 Feb 07;: Authors: O'Donovan AN, Herisson FM, Fouhy F, Ryan PM, Whelan D, Johnson CN, Cluzel G, Ross RP, Stanton C, Caplice NM Abstract Metabolic syndrome (MetS) is a combination of cardiovascular risk factors including obesity, hyperlipidemia, hypertension, insulin resistance, non-alcoholic fatty liver disease and diastolic heart failure. This syndrome has been identified as one of the greatest global health challenges of the 21st century. Herein, we examine in a porcine model of diet-induced MetS whether cardiovascular, metabolic, gut microbiota and functional metataxonomic changes mimic those observed in human studies. Landrace pigs with mineralocorticoid-induced hypertension fed a high-fat, salt and sugar diet (HFD) over 12 weeks were assessed for hyperlipidemia, hyperinsulinemia, immunohistologic, echocardiographic and hemodynamic parameters, as well as assessment of microbiome phenotype and functionality through 16S rRNA gene sequencing, phylogenetic and meta-taxonomic analysis. All MetS animals when compared to controls developed obesity, hyperlipidemia, insulin resistance, hypertension, fatty liver, structural cardiovascular changes including left ventricular hypertrophy and left atrial enlargement, and increased circulating saturated fatty acid levels, in keeping with the human phenotype. A reduction in alpha diversity an...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research