Current Concepts in Breast Cancer Genomics: An Evidence Based Review by the CGC Breast Cancer Working Group

Current diagnosis and management of breast cancer relies primarily upon histology, clinical and pathologic staging, and a limited set of biomarkers for hormone therapy and anti-HER2 therapy. The principal biomarkers are estrogen receptor alpha (ER- α) (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2/neu, ERBB2). Pathologic work up of invasive tumors includes immunohistochemistry to evaluate for ER and PR expression, and immunohistochemistry and/or in situ hybridization (ISH) for determination of HER2 statu s.

Source: Cancer Genetics and Cytogenetics - February 7, 2020 Category: Genetics & Stem Cells Authors: Katherine B. Geiersbach, Hui Chen, Rajyasree Emmadi, Gloria T. Haskell, Xinyan Lu, Yajuan J. Liu, Karen Swisshelm Source Type: research