Pseudomonas aeruginosa antibody response in cystic fibrosis decreases rapidly following lung transplantation

Chronic lung infection with the opportunistic pathogen Pseudomonas aeruginosa (PA) is common in patients with cystic fibrosis (CF) due to reduced mucociliary clearance and is the major contributor to mortality in CF [1]. Colonisation occurs in the paranasal sinuses where the inflammation is predominantly mediated by non-phlogistic immunoglobulin A (IgA) and from where PA is aspirated to the lungs. PA in CF patients is located in the airways and not systemically due to the aerobic conditions in combination with the reduced clearance of mucus in CF making the lungs and sinuses the ideal growth places for PA [2].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research