Optimization of Spectral Domain Optical Coherence Tomography and Visual Evoked Potentials to Identify Unilateral Optic Neuritis

Conclusions: The inter-eye GCIPL difference is a powerful index for identifying unilateral optic nerve lesion, while the inter-eye RNFL difference and 95th percentile normal VEP latency had very good sensitivity and specificity. These measures can be useful in the evaluation of the first demyelinating event of MS and therefor can facilitate early diagnosis and therapy.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

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ConclusionPhenytoin is not probably safe and effective as neuroprotection after acute ON. Further investigation with other sodium channel inhibitors could be considered.
Source: Neurological Sciences - Category: Neurology Source Type: research
Conclusions Although the effect of demyelination on axonal survival has been demonstrated in experimental studies, our results provide first clinically meaningful evidence that chronic demyelination is associated with progressive axonal loss in human MS.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: All Imaging, Optic nerve, Evoked Potentials/Visual, Multiple sclerosis, Optic neuritis; see Neuro-ophthalmology/Optic Nerve Article Source Type: research
Background: Patients with multiple sclerosis (MS) experience progressive thinning in optical coherence tomography (OCT) measures of neuroaxonal structure regardless of optic neuritis history. Few prospective studies have investigated the effects of disease-modifying therapies on neuroaxonal degeneration in the retina. Alemtuzumab is a monoclonal antibody shown to be superior to interferon β-1a in treating relapsing–remitting MS (RRMS). The purpose of this study was to assess the effects of alemtuzumab and first-line injectable treatments on OCT measures of neuroaxonal structure including peripapillary retinal ...
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Original Contribution Source Type: research
AbstractAutoimmune optic neuritis (AON), a model of multiple sclerosis ‐associated optic neuritis, is accompanied by degeneration of retinal ganglion cells (RGCs) and optic nerve demyelination and axonal loss. In order to investigate the role of N‐methyl‐D‐aspartate (NMDA) receptors in mediating RGC degeneration, upstream changes in the optic nerve actin cytosk eleton and associated deterioration in visual function, we induced AON in Brown Norway rats by immunisation with myelin oligodendrocyte glycoprotein. Subsequently, visual acuity was assessed by recording visual evoked potentials and electroretinograms prior ...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusion A single history of ON induces long-term structural damage within the retina and OR suggestive of both retrograde and anterograde neuroaxonal degeneration.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: MRI, DWI, Evoked Potentials/Visual, Multiple sclerosis, Optic neuritis; see Neuro-ophthalmology/Optic Nerve Article Source Type: research
The chronic involvement of the afferent visual system in multiple sclerosis (MS) is a powerful model to understand the temporal course and functional relevance of neurodegeneration because it is very well distinguishable from neighboring structures and offers quantifiable structural and functional metrics. Optical coherence tomography (OCT) of the retina and diffusion tensor imaging (DTI)-based tractography of the optic radiation have proven to provide sensitive markers for neurodegeneration of the visual pathway in MS.1,2 OCT-derived neuroaxonal retinal damage, represented by thinning of the retinal nerve fiber layer (RNF...
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: MRI, DWI, Evoked Potentials/Visual, Multiple sclerosis, Optic neuritis; see Neuro-ophthalmology/Optic Nerve Editorial Source Type: research
Conclusions Retinal structural damage develops rapidly following acute ON and is associated with subsequent functional visual deficits. Our results also suggest bilateral retinal pathology following unilateral ON, possibly caused by subclinical involvement of the contralateral NON eyes. Moreover, our data may assist in clinical trial planning in studies targeting tissue damage in acute ON.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Retina, Visual loss, Multiple sclerosis, Optic neuritis; see Neuro-ophthalmology/Optic Nerve Article Source Type: research
In conclusion, targeting the dysfunctional complex I usingNDI1 gene can be an approach to address axonal and neuronal loss responsible for permanent disability in MS that is unaltered by current disease modifying drugs.
Source: Molecular Neurobiology - Category: Neurology Source Type: research
In this study, we determine longitudinal changes in retinal layer thickness in ON.Methods: Thirty ON patients underwent optical coherence tomography (OCT) and visual function testing at baseline, one month, and 6 months.Results: Mean GCIPL thickness decreased at one month relative to baseline from 63.6 ± 7.5 μm to 57.3 ± 6.8 µm in 3 mm ring (P
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Semin Neurol 2019; 39: 711-717 DOI: 10.1055/s-0039-1700528Optical coherence tomography (OCT) grew out of a convergence of rapid advancements in femtoseconds optics research and fiber optic commercial technology. The basic concept of OCT is to “see” into tissues using light echoes, analogous to the sound echoes of ultrasonography. Multiple A-scans are assembled into a B-scan two-dimensional image of the tissue of interest. Retina is an ideal tissue for evaluation by OCT, since the eye is designed to minimize light scattering through the anterior chamber and vitreous. OCT has had a significant impact on the field...
Source: Seminars in Neurology - Category: Neurology Authors: Tags: Review Article Source Type: research
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