Importance of osteocyte-mediated regulation of bone remodelling in inflammatory bone disease.

Importance of osteocyte-mediated regulation of bone remodelling in inflammatory bone disease. Swiss Med Wkly. 2020 Jan 27;150:w20187 Authors: Intemann J, De Gorter DJJ, Naylor AJ, Dankbar B, Wehmeyer C Abstract Although the impact of osteoblast-osteoclast crosstalk in bone remodelling has been intensively studied, the importance of osteocytes, descendants of osteoblasts, in this process has for a long time been neglected. During their embedding phase, osteocytes undergo considerable phenotypic transformation, from a cuboidal, highly metabolically active osteoblast secreting extracellular matrix to a small, stellate, quiescent osteocyte with numerous long dendrites. Osteocytes are encysted in cavities (lacunae) and their dendritic extensions are located in tunnels (canaliculi) forming a remarkable, highly branched, lacunar-canalicular signalling network that spans the entire bone matrix. Osteocytes and their dendrites can communicate directly with each other and through the release of effector proteins such as sclerostin and nuclear factor κB ligand (RANKL), influence osteoblast and osteoclast formation. This allows osteocytes embedded within the bone matrix to communicate and coordinate activity of cells on the bone surface to adapt to mechanical needs and hormonal changes. Besides their importance in sustaining physiological bone homeostasis, accumulating evidence suggests that dysregulated osteocyte function and alterations in the osteocyte lacun...
Source: Swiss Medical Weekly - Category: General Medicine Authors: Tags: Swiss Med Wkly Source Type: research

Related Links:

One of the biggest challenges of this unsettling time is the isolation we feel as we’re separated from friends and family, all the people for whom we care most deeply. But just being alone is only part of the difficulty. Our sense of remoteness is intensified by a pall of unease we can’t define: Loss and sorrow are also in the air. We fear losing—or we may have already lost—people we love. And when we work up the courage to look beyond our individual personal spheres, we see that many people who have made our world better, in big and small ways, have vanished before we were ready to let them go. But...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 feature remembrance Source Type: news
Authors: Köklü H, Üstün H, Köklü S PMID: 32233283 [PubMed - in process]
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
This study examined weight reduction as well as smoking as potential modifiable risk factors for PsA.The British Journal of Dermatology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news
Publication date: Available online 1 April 2020Source: Journal of Ayurveda and Integrative MedicineAuthor(s): Sanjeev Rastogi
Source: Journal of Ayurveda and Integrative Medicine - Category: Complementary Medicine Source Type: research
The original article has been corrected.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
This study aimed to assess clinical outcomes in patients who required syndesmosis fixation in the presence of arthroscopically proven instability, the hypothesis being that a delay to treatment would be associated with worse function.MethodA retrospective cohort study was performed of patients with dynamic instability requiring fixation between the years of 2010 –2016. The procedures were performed by two foot and ankle fellowship trained orthopaedic surgeons, over three hospital sites. Patients were classified into three groups based on the time since injury to surgery, acute syndesmotic injury (  6 mont...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
The prenatal and early postnatal period is highly sensitive to environmental exposures that may interfere with the developmental programming of the immune system leading to an altered disease risk in later life. To clarify the role of early influences in activation or exacerbation of autoimmune diseases like rheumatoid arthritis (RA) we investigated the effect of maternal exposure during the prenatal and lactational period of DBA/1 mice to the plasticizer benzyl butyl phthalate (BBP) on the development of RA in the offspring. Using a mild collagen-induced arthritis (CIA) model, maternal BBP-exposure increased both the prev...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Authors: Conti P, Gallenga CE, Tetè G, Caraffa A, Ronconi G, Younes A, Toniato E, Ross R, Kritas SK Abstract SARS-CoV-2, also referred to as CoV-19, is an RNA virus which can cause severe acute respiratory diseases (COVID-19), with serious infection of the lower respiratory tract followed by bronchitis, pneumonia and fibrosis. The severity of the disease depends on the efficiency of the immune system which, if it is weak, cannot stem the infection and its symptoms. The new CoV-19 spreads in the population at a rate of 0.8-3% more than normal flu and mostly affects men, since immune genes are more expressed o...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Conditions:   Decision Making, Shared;   Arthroplasty, Replacement, Knee;   Arthroplasty, Replacement, Hip;   Osteoarthritis, Knee;   Osteoarthritis, Hip;   Artificial Intelligence Intervention:   Other: ERVIN Sponsors:   Northern Orthopaedic Division, Denmark;   Aalborg University Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Condition:   Knee Osteoarthritis Interventions:   Other: Standard Physcial Therapy;   Other: Intermittent Mechanical Traction;   Other: Continuous Mechanical Traction Sponsor:   Prince Sultan Military College of Health Sciences Not yet recruiting
Source: - Category: Research Source Type: clinical trials
More News: Arthritis | Biology | General Medicine | Hormones | Orthopaedics | Osteoarthritis | Osteomyelitis | Osteoporosis | Rheumatoid Arthritis | Rheumatology | Study | Switzerland Health