Nanocurcumin inhibits angiogenesis via down-regulating hif1a/vegfa signaling in Zebrafish.

Nanocurcumin inhibits angiogenesis via down-regulating hif1a/vegfa signaling in Zebrafish. Curr Neurovasc Res. 2020 Feb 07;: Authors: Cao Z, He S, Peng Y, Liao X, Lu H Abstract Curcumin has anti-inflammatory, antioxidant and anticancer properties. Despite the considerable promise that curcumin is an efficacious and safe compound for multiple medicinal benefits, there are some demerits with respect to the therapeutic effectiveness of curcumin, namely, poor stability and solubility, and its role in angiogenesis in vivo is still not yet clear. More recently, the approach of biodegradable polymer nanoparticles has been developed. This offers promise for therapeutic effectiveness of curcumin by increasing its bioavailability, solubility and retention time. Here, we compared the medicinal effectiveness of curcumin and nanocurcumin (NC), and found that nanocurcumin can inhibit angiogenesis more effectively than curcumin in zebrafish. Tests of proliferation and apoptosis showed no difference between nanocurcumin treated and wild-type embryos. qPCR and in situ hybridization experiments indicated that the vegf signaling pathway genes, vegfa, vegfc and flt4 were all down-regulated after nanocurcumin treatment, and vegfa over-expression rescued the vascular defective phenotype. Moreover, hif1a expression was also decreased and hif1a over-expression also rescued the vascular defective phenotype but Notch signaling pathway had no difference after ...
Source: Current Neurovascular Research - Category: Neurology Authors: Tags: Curr Neurovasc Res Source Type: research