Efecto de los síntomas psiquiátricos y calidad de vida sobre el desempeño cognitivo en el VHC

ConclusionesEn consonancia con estudios previos, nuestros resultados muestran una relación entre la memoria verbal y el efecto del VHC en el cerebro, aunque el presente estudio no ha podido relacionar la afectación frontoestriatal de los pacientes con VHC con su rendimiento cognitivo.AbstractObjectiveReduced performance in several cognitive domains has been repeatedly related to hepatitis C virus (HCV). Nevertheless, there is no consensus about the severity or cognitive profile. Moreover, other possible influential variables are scarcely controlled. The aim of this study is to define the specific cognitive profile in HCV after controlling for confounding variables.MethodsForty-two HCV patients were distributed in 2 groups according to the presence of co-infection with human immunodeficiency virus; a third group with 22 healthy controls was also included. The neuropsychological assessment included tests that assess processing speed, executive functioning, verbal memory, visual memory and working memory. Measures of depression (BDI), anxiety (HAM-A), fatigue (MAF), anhedonia (PAS), insomnia (ISI), quality of life (SF-36) and history of drug abuse (DAST-20) were taken in order to explore differences among groups and to control for their possible influence on cognitive performance.ResultsHCV patients (including human immunodeficiency virus-coinfection) performed significantly worse in all cognitive measures. However, when the effect of BDI, HAM-A, MAF, ISI, SF-36 & DAST-20...
Source: Revista de Psiquiatria y Salud Mental - Category: Psychiatry Source Type: research