Role of Nuclear factor kappa B (NF- κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach.

Role of Nuclear factor kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach. Curr Neuropharmacol. 2020 Feb 07;: Authors: Singh S, Singh TG Abstract A transcriptional regulatory nuclear factor kappa B (NF-κB) protein is a modulator of cellular biological activity via binding to a promoter region in the nucleus and transcribing various protein genes. The recent research implicated the intensive role of nuclear factor kappa B (NF-κB) in diseases like autoimmune disorder, inflammatory, cardiovascular and neurodegenerative diseases. Therefore, targeting the nuclear factor kappa B (NF-κB) protein offers a new opportunity as therapeutic approach. Activation of IκB kinase/NF-κB signalling pathway leads to development of various pathological conditions in human being, such as neurodegenerative, inflammatory disorders, autoimmune diseases and cancer. Therefore, the transcriptional activity of IκB kinase/NF-κB is strongly regulated at various cascade pathways. The nuclear factor NF-kB pathway plays a major role in expression of pro-inflammatory genes including cytokines, chemokines, and adhesion molecules. In response to the diverse stimuli, the cytosolic sequestered NF-κB in an inactivated form by binding with an inhibitor molecule protein (IkB) gets phosphorylated and translocated into the nucleus further transcribing various genes necessary for modifying various cellular functions. The various researches...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research