Silicon-hydroxyapatite‒glycerohydrogel as a promising biomaterial for dental applications

Publication date: Available online 7 February 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): T.G. Khonina, O.N. Chupakhin, V.Ya. Shur, A.P. Turygin, V.V. Sadovsky, Yu.V. Mandra, E.A. Sementsova, A.Yu Kotikova, A.V. Legkikh, E.Yu Nikitina, E.A. Bogdanova, N.A. SabirzyanovAbstractNanocomposite silicon-hydroxyapatite‒glycerohydrogel (Si-HA‒glycerohydrogel) with different hydroxyapatite (HA) contents of 0.75 and 1.75 wt.% and the same Si content (2.04 wt.%) was obtained by the sol‒gel method. Silicon tetraglycerolate in the form of glycerol solution was used as a biocompatible precursor and HА in the form of aqueous colloidal suspension – as a template and property modifier. Transmission electron microscopy was applied to demonstrate that there are nanoscale HA particles that are in the crystalline state. For the first time, using the atomic force microscopy method, the remineralizing properties of Si-HA‒glycerohydrogel were studied on human teeth extracted for orthodontic reasons. It was found that Si-HA‒glycerohydrogel containing 1.75 wt.% HA has a pronounced remineralizing effect. Immersion of tooth enamel samples in the gel for one month significantly reduces roughness and makes the enamel surface more uniform. Silicon contained in glycerolates in a biologically active and accessible form exerts an additional positive effect on the process of remineralization of tooth enamel. By the energy dispersive X-ray analysis, it was demonstrated that th...

Source: Colloids and Surfaces B: Biointerfaces - February 8, 2020 Category: Biochemistry Source Type: research