The new koninginins T-U from Phomopsis stipata, an endophytic fungus isolated from Styrax camporum Pohl

Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Carolina R. Biasetto, Andressa Somensi, Renata Sordi, Vanessa M. Chapla, Samad N. Ebrahimi, Geraldo H. Silva, Helder L. Teles, Vanderlan da S. Bolzani, Maria Cláudia M. Young, Ludwig H. Pfenning, Angela R. AraujoAbstractTwo new polyketides, named koninginin T (1) and U (2), were isolated from Phomopsis stipata - an endophytic fungus isolated from Styrax camporum Pohl. The structures of polyketides 1 and 2 were defined through the analysis of spectroscopic data. Antifungal and acetylcholinesterase inhibitory activities of these compounds were evaluated using TLC bioautographic assays. Compounds 1 and 2 displayed moderate antifungal activity and compound 1 showed acetylcholinesterase inhibitory activity.Graphical abstract

Source: Phytochemistry Letters - February 8, 2020 Category: Chemistry Source Type: research