Investigation of key miRNAs and their target genes involved in cell apoptosis during intervertebral disc degeneration development using bioinformatics methods.

CONCLUSIONS: The expression of GSK3B may be coregulated by miR-4306, miR-185-5p, miR-486-5p, hsa-let-7f-1-3p, and miR-631 and may affect IDD development. Besides, miR-185-5p and miR-3675-3p may control nucleus pulposus (NP) cell apoptosis through the MAPK signaling pathway in IDD patients. VEGFA expression may be regulated by miR-631, and help maintain NP cell survival in IDD patients. Our findings may help guide further research into the role of miRNAs in IDD progression. PMID: 32031354 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32031354?dopt=Abstract

Source: Journal of Neurosurgical Sciences - February 8, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research