Olanzapine, risperidone, and aripiprazole use in children and adolescents with Autism Spectrum Disorders

Publication date: April 2020Source: Research in Autism Spectrum Disorders, Volume 72Author(s): Selma Tural Hesapcioglu, Mehmet Fatih Ceylan, Meryem Kasak, Cansu Pınar SenAbstractBackgroundThe aim of this study is to examine the use of olanzapine, risperidone and aripiprazole in autism spectrum disorders (ASD) in terms of their effects and side effects.MethodsASD patients that had been initiated to be treated with one of the three antipsychotics that continued for a minimum of eight weeks were included in the study, retrospectively. The participants were recruited with 20 olanzapine using patients (2.5−10 mg/day) in comparison with 42 risperidone (1−4 mg/day) and 40 aripiprazole (3−15 mg/day) using patients that are using the matched equivalent chlorpromazine doses of the antipsychotics between the same time period.ResultsAll three antipsychotics significantly decreased all of the ABC subscales scores in eight weeks. Sleepiness/sedation, increased duration of sleep, and weight gain were the most common side effects of the three antipsychotics and they were more frequent with olanzapine than with the others (X2 = 26.9, p
Source: Research in Autism Spectrum Disorders - Category: Psychiatry Source Type: research

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Abstract OBJECTIVE: We investigated parental use of conventional therapies and complementary and alternative medicine (CAM) for children with autism in Jordan. METHOD: This prospective cross-sectional study was conducted from February 2018 through December 2018 at the paediatric neurology clinics of three tertiary referral hospitals in Jordan. The accompanying parent was interviewed to complete a structured questionnaire. RESULTS: 274 parents were interviewed. The most common medications used were those to treat hyperactivity (150; 54.7 %), anticonvulsants (60; 21.9 %), and sleep aids (6; 2.1 %). CAM was...
Source: Complementary Therapies in Medicine - Category: Complementary Medicine Authors: Tags: Complement Ther Med Source Type: research
CONCLUSIONS: Consequently, these herbs, in theory at least, appear to be suitable candidates within an overall management strategy for those on the autism spectrum. PMID: 31721693 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
Autism Spectrum Disorders comprise conditions that may affect cognitive development, motor skills, social interaction, communication, and behavior. This set of functional deficits often results in lack of independence for the diagnosed individuals, and severe distress for patients, families, and caregivers. There is a mounting body of evidence indicating the effectiveness of pure cannabidiol (CBD) and CBD-enriched Cannabis sativa extract (CE) for the treatment of autistic symptoms in refractory epilepsy patients. There is also increasing data support for the hypothesis that non-epileptic autism shares underlying etiologica...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusions:The absence of demographic or clinical predictors of OSA supports using general indications for PSG in children with ASD.Citation:Tomkies A, Johnson RF, Shah G, Caraballo M, Evans P, Mitchell RB. Obstructive sleep apnea in children with autism.J Clin Sleep Med. 2019;15(10):1469–1476.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
CASE: Alex is a 14-year-old Portuguese-American boy with a psychiatric history starting at age 5 who presents to your primary care practice after an insurance change. He was delivered prematurely at 32 weeks and diagnosed with congenital hypothyroidism at the age of 6 weeks and growth hormone deficiency at the age of 2 years; he is in active treatment for both. He otherwise met developmental milestones on time yet continues to have significant fatigue despite adequate sleep and vitamin D supplementation. His family history is remarkable for maternal anxiety, depression, suicidal thoughts, and previous attempted suicide...
Source: Journal of Developmental and Behavioral Pediatrics - Category: Child Development Tags: Challenging Case Source Type: research
ConclusionsThese results have clinical significance as sleep and EF deficits may identify an ASD subgroup that is at increased risk for a comorbid ADHD diagnosis.
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
ConclusionsThese studies demonstrate child sleep problems are associated with poorer parent mental health and higher parenting stress.ImplicationsFuture longitudinal research including multiple measurements of child sleep problems and family functioning is required to clarify the directionality of associations. Such knowledge is key in adapting sleep interventions to better meet the needs of children with ADHD or ASD and their families.
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
In conclusion, this review highlights the importance for clinicians to investigate for the presence of chronic nightmares along with other sleep difficulties (most commonly, insomnia and sleep apnea), to consider the potential influence of nightmares on the course of the primary mental disorder, and to be prepared to grant access to treatments targeting nightmares. (PsycINFO Database Record (c) 2019 APA, all rights reserved)
Source: Dreaming - Category: Psychiatry & Psychology Source Type: research
People living with autism are sensitive to the social world and the environment in general. They could experience great difficulties in social situations, have anxieties, fears, phobias, or sensory sensitivities. On the other hand, they could be on good terms with technologies: social stories apps can navigate them in difficult situations, virtual and augmented reality can offer a safe space for them to exercise, and artificial intelligence helps in early detection. We scoured the ground carefully and hereby present you the intersections of autism and digital health. Raymond Babbitt’s heritage and the chronicles ...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine AI app AR artificial intelligence autism digital digital health digital technology games genetics health app health apps Innovation virtual reality VR Source Type: blogs
Authors: Tandon PS, Sasser T, Gonzalez ES, Whitlock KB, Christakis DA, Stein MA Abstract Background: Children with attention deficit hyperactivity disorder (ADHD) are at increased risk for poor health and obesity. The authors describe obesity-related movement behaviors in children with ADHD, determine higher risk groups, and compare with children with other disorders. Methods: Physical activity (PA), sleep, and screen time of children with ADHD (aged 6-18 y) were compared with recommendations and with behaviors of children with autism, asthma, and a normative group using 2011 National Survey of Child Health da...
Source: Journal of Physical Activity and Health - Category: Sports Medicine Tags: J Phys Act Health Source Type: research
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