Bacterial biofilm in colorectal cancer: What is the real mechanism of action?

Publication date: Available online 8 February 2020Source: Microbial PathogenesisAuthor(s): Rasoul Mirzaei, Hamed Mirzaei, Mohammad Yousef Alikhani, Mohammad Sholeh, Mohammad Reza Arabestani, Masoud Saeedijam, Sajad Karampoor, Yaghoub Ahmadyousefi, Mohammad Shokri Moghadam, Gholam Reza Irajian, Hamze Hasanvand, Rasoul YousefimashoufAbstractHuman colorectal cancer is the third most common cancer around the world. Colorectal cancer has various risk factors, but current works have bolded a significant activity for the microbiota of the human colon in the development of this disease. Bacterial biofilm has been mediated to non-malignant pathologies like inflammatory bowel disease but has not been fully documented in the setting of colorectal cancer. The investigation has currently found that bacterial biofilm is mediated to colon cancer in the human and linked to the location of human cancer, with almost all right-sided adenomas of colon cancers possessing bacterial biofilm, whilst left-sided cancer is rarely biofilm positive. The profound comprehension of the changes in colorectal cancer can provide interesting novel concepts for anticancer treatments. In this review, we will summarize and examine the new knowledge about the links between colorectal cancer and bacterial biofilm.

Source: Microbial Pathogenesis - February 8, 2020 Category: Infectious Diseases Source Type: research