Genome-wide association analysis of Parkinson ’s disease and schizophrenia reveals shared genetic architecture and identifies novel risk loci

Parkinson ’s disease (PD) and schizophrenia (SCZ) are heritable brain disorders that both involve dysregulation of the dopaminergic system. Epidemiological studies have reported potential comorbidity between the disorders, and movement disturbances are common in SCZ patients before treatment with antipsycho tic drugs. Despite this, little is known about shared genetic etiology between the disorders.

Source: Biological Psychiatry - February 6, 2020 Category: Psychiatry Authors: Olav B. Smeland, Alexey Shadrin, Shahram Bahrami, Iris Broce, Martin Tesli, Oleksandr Frei, Katrine V. Wirgenes, Kevin S. O ’Connell, Florian Krull, Francesco Bettella, Nils Eiel Steen, Leo Sugrue, Yunpeng Wang, Per Svenningsson, Manu Sharma, Lasse Pihl Tags: Archival Report Source Type: research